PittsburghV1, Main, Exploration, bibRecord, 000B74

Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis

Identifieur interne : 000B74 ( Main/Exploration ); précédent : 000B73; suivant : 000B75

Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis

Auteurs : Tinh-Hai Collet ; Douglas C. Bauer ; Anne R. Cappola ; Bj Rn O. Svold ; Stefan Weiler ; Eric Vittinghoff ; Jacobijn Gussekloo ; Alexandra Bremner ; Wendy P. J. Den Elzen ; Rui M. B. Maciel ; Mark P. J. Vanderpump ; Jacques Cornuz ; Marcus Dörr ; Henri Wallaschofski ; Anne B. Newman ; José A. Sgarbi ; Salman Razvi ; Henry Völzke ; John P. Walsh ; Drahomir Aujesky ; Nicolas Rodondi

Source :

The Journal of Clinical Endocrinology and Metabolism [ 0021-972X ] ; 2014.

RBID : PMC:4154087

Abstract

Context:

Subclinical hypothyroidism has been associated with increased risk of coronary heart disease (CHD), particularly with thyrotropin levels of 10.0 mIU/L or greater. The measurement of thyroid antibodies helps predict the progression to overt hypothyroidism, but it is unclear whether thyroid autoimmunity independently affects CHD risk.

Objective:

The objective of the study was to compare the CHD risk of subclinical hypothyroidism with and without thyroid peroxidase antibodies (TPOAbs).

Data Sources and Study Selection:

A MEDLINE and EMBASE search from 1950 to 2011 was conducted for prospective cohorts, reporting baseline thyroid function, antibodies, and CHD outcomes.

Data Extraction:

Individual data of 38 274 participants from six cohorts for CHD mortality followed up for 460 333 person-years and 33 394 participants from four cohorts for CHD events.

Data Synthesis:

Among 38 274 adults (median age 55 y, 63% women), 1691 (4.4%) had subclinical hypothyroidism, of whom 775 (45.8%) had positive TPOAbs. During follow-up, 1436 participants died of CHD and 3285 had CHD events. Compared with euthyroid individuals, age- and gender-adjusted risks of CHD mortality in subclinical hypothyroidism were similar among individuals with and without TPOAbs [hazard ratio (HR) 1.15, 95% confidence interval (CI) 0.87–1.53 vs HR 1.26, CI 1.01–1.58, P for interaction = .62], as were risks of CHD events (HR 1.16, CI 0.87–1.56 vs HR 1.26, CI 1.02–1.56, P for interaction = .65). Risks of CHD mortality and events increased with higher thyrotropin, but within each stratum, risks did not differ by TPOAb status.

Conclusions:

CHD risk associated with subclinical hypothyroidism did not differ by TPOAb status, suggesting that biomarkers of thyroid autoimmunity do not add independent prognostic information for CHD outcomes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154087

DOI: 10.1210/jc.2014-1250
PubMed: 24915118
PubMed Central: 4154087

Affiliations:

Le document en format XML

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<author><name sortKey="Collet, Tinh Hai" sort="Collet, Tinh Hai" uniqKey="Collet T" first="Tinh-Hai" last="Collet">Tinh-Hai Collet</name>
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<author><name sortKey="Bauer, Douglas C" sort="Bauer, Douglas C" uniqKey="Bauer D" first="Douglas C." last="Bauer">Douglas C. Bauer</name>
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<author><name sortKey="Cappola, Anne R" sort="Cappola, Anne R" uniqKey="Cappola A" first="Anne R." last="Cappola">Anne R. Cappola</name>
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<author><name sortKey=" Svold, Bj Rn O" sort=" Svold, Bj Rn O" uniqKey=" Svold B" first="Bj Rn O." last=" Svold">Bj Rn O.  Svold</name>
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<author><name sortKey="Weiler, Stefan" sort="Weiler, Stefan" uniqKey="Weiler S" first="Stefan" last="Weiler">Stefan Weiler</name>
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<author><name sortKey="Gussekloo, Jacobijn" sort="Gussekloo, Jacobijn" uniqKey="Gussekloo J" first="Jacobijn" last="Gussekloo">Jacobijn Gussekloo</name>
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<author><name sortKey="Bremner, Alexandra" sort="Bremner, Alexandra" uniqKey="Bremner A" first="Alexandra" last="Bremner">Alexandra Bremner</name>
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<author><name sortKey="Den Elzen, Wendy P J" sort="Den Elzen, Wendy P J" uniqKey="Den Elzen W" first="Wendy P. J." last="Den Elzen">Wendy P. J. Den Elzen</name>
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<author><name sortKey="Maciel, Rui M B" sort="Maciel, Rui M B" uniqKey="Maciel R" first="Rui M. B." last="Maciel">Rui M. B. Maciel</name>
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<author><name sortKey="Cornuz, Jacques" sort="Cornuz, Jacques" uniqKey="Cornuz J" first="Jacques" last="Cornuz">Jacques Cornuz</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis</title>
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<author><name sortKey="Maciel, Rui M B" sort="Maciel, Rui M B" uniqKey="Maciel R" first="Rui M. B." last="Maciel">Rui M. B. Maciel</name>
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<series><title level="j">The Journal of Clinical Endocrinology and Metabolism</title>
<idno type="ISSN">0021-972X</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Context:</title>
<p>Subclinical hypothyroidism has been associated with increased risk of coronary heart disease (CHD), particularly with thyrotropin levels of 10.0 mIU/L or greater. The measurement of thyroid antibodies helps predict the progression to overt hypothyroidism, but it is unclear whether thyroid autoimmunity independently affects CHD risk.</p>
</sec>
<sec><title>Objective:</title>
<p>The objective of the study was to compare the CHD risk of subclinical hypothyroidism with and without thyroid peroxidase antibodies (TPOAbs).</p>
</sec>
<sec><title>Data Sources and Study Selection:</title>
<p>A MEDLINE and EMBASE search from 1950 to 2011 was conducted for prospective cohorts, reporting baseline thyroid function, antibodies, and CHD outcomes.</p>
</sec>
<sec><title>Data Extraction:</title>
<p>Individual data of 38 274 participants from six cohorts for CHD mortality followed up for 460 333 person-years and 33 394 participants from four cohorts for CHD events.</p>
</sec>
<sec><title>Data Synthesis:</title>
<p>Among 38 274 adults (median age 55 y, 63% women), 1691 (4.4%) had subclinical hypothyroidism, of whom 775 (45.8%) had positive TPOAbs. During follow-up, 1436 participants died of CHD and 3285 had CHD events. Compared with euthyroid individuals, age- and gender-adjusted risks of CHD mortality in subclinical hypothyroidism were similar among individuals with and without TPOAbs [hazard ratio (HR) 1.15, 95% confidence interval (CI) 0.87–1.53 vs HR 1.26, CI 1.01–1.58, <italic>P</italic>
 for interaction = .62], as were risks of CHD events (HR 1.16, CI 0.87–1.56 vs HR 1.26, CI 1.02–1.56, <italic>P</italic>
 for interaction = .65). Risks of CHD mortality and events increased with higher thyrotropin, but within each stratum, risks did not differ by TPOAb status.</p>
</sec>
<sec><title>Conclusions:</title>
<p>CHD risk associated with subclinical hypothyroidism did not differ by TPOAb status, suggesting that biomarkers of thyroid autoimmunity do not add independent prognostic information for CHD outcomes.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey=" Svold, Bj Rn O" sort=" Svold, Bj Rn O" uniqKey=" Svold B" first="Bj Rn O." last=" Svold">Bj Rn O.  Svold</name>
<name sortKey="Aujesky, Drahomir" sort="Aujesky, Drahomir" uniqKey="Aujesky D" first="Drahomir" last="Aujesky">Drahomir Aujesky</name>
<name sortKey="Bauer, Douglas C" sort="Bauer, Douglas C" uniqKey="Bauer D" first="Douglas C." last="Bauer">Douglas C. Bauer</name>
<name sortKey="Bremner, Alexandra" sort="Bremner, Alexandra" uniqKey="Bremner A" first="Alexandra" last="Bremner">Alexandra Bremner</name>
<name sortKey="Cappola, Anne R" sort="Cappola, Anne R" uniqKey="Cappola A" first="Anne R." last="Cappola">Anne R. Cappola</name>
<name sortKey="Collet, Tinh Hai" sort="Collet, Tinh Hai" uniqKey="Collet T" first="Tinh-Hai" last="Collet">Tinh-Hai Collet</name>
<name sortKey="Cornuz, Jacques" sort="Cornuz, Jacques" uniqKey="Cornuz J" first="Jacques" last="Cornuz">Jacques Cornuz</name>
<name sortKey="Den Elzen, Wendy P J" sort="Den Elzen, Wendy P J" uniqKey="Den Elzen W" first="Wendy P. J." last="Den Elzen">Wendy P. J. Den Elzen</name>
<name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name>
<name sortKey="Gussekloo, Jacobijn" sort="Gussekloo, Jacobijn" uniqKey="Gussekloo J" first="Jacobijn" last="Gussekloo">Jacobijn Gussekloo</name>
<name sortKey="Maciel, Rui M B" sort="Maciel, Rui M B" uniqKey="Maciel R" first="Rui M. B." last="Maciel">Rui M. B. Maciel</name>
<name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<name sortKey="Razvi, Salman" sort="Razvi, Salman" uniqKey="Razvi S" first="Salman" last="Razvi">Salman Razvi</name>
<name sortKey="Rodondi, Nicolas" sort="Rodondi, Nicolas" uniqKey="Rodondi N" first="Nicolas" last="Rodondi">Nicolas Rodondi</name>
<name sortKey="Sgarbi, Jose A" sort="Sgarbi, Jose A" uniqKey="Sgarbi J" first="José A." last="Sgarbi">José A. Sgarbi</name>
<name sortKey="Vanderpump, Mark P J" sort="Vanderpump, Mark P J" uniqKey="Vanderpump M" first="Mark P. J." last="Vanderpump">Mark P. J. Vanderpump</name>
<name sortKey="Vittinghoff, Eric" sort="Vittinghoff, Eric" uniqKey="Vittinghoff E" first="Eric" last="Vittinghoff">Eric Vittinghoff</name>
<name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
<name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name>
<name sortKey="Weiler, Stefan" sort="Weiler, Stefan" uniqKey="Weiler S" first="Stefan" last="Weiler">Stefan Weiler</name>
</noCountry>
</tree>
</affiliations>
</record>

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Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis

Thyroid Antibody Status, Subclinical Hypothyroidism, and the Risk of Coronary Heart Disease: An Individual Participant Data Analysis

Source :

Abstract

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